A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C08G 65/335 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2723263
The present invention provides polymeric prodrugs including an intracellular releasable disulfide linker for the delivery of oligonucleotides. Methods of making the compounds as well as methods of delivering nucleic acids to tumor cells in a mammal using the same are also provided.
La présente invention concerne des promédicaments polymères comprenant un lieur disulfure intracellulaire libérable pour la délivrance doligonucléotides. La présente invention concerne également des procédés de fabrication des composés ainsi que des procédés de délivrance dacides nucléiques à des cellules tumorales chez un mammifère en les utilisant.
Reddy Prasanna
Zhao Hong
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Enzon Pharmaceuticals Inc.
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