Polymeric systems for drug delivery and uses thereof

Details Polymeric systems for drug delivery and uses thereof Polymeric systems for drug delivery and uses thereof

C - Chemistry, Metallurgy

08

G

C08G 63/664 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 47/34 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2348922

Biodegradable polymeric implants can provide a safe and efficient means to deliver drugs in the treatment of various diseases. Although a polymeric drug delivery system can be implanted as a solid device within a subject, it is also possible to administer such a system as an injectable liquid which solidifies in vivo. An improved formulation of a polymeric drug delivery system comprises a water insoluble copolymer that is a solid or wax at 37 ~C, a water soluble polymer that is a liquid at 25 ~C, and a hydrophobic drug. These drug delivery systems can be administered by injection, and do not require the use of a toxic curing agent or inconvenient temperature manipulations.

L'invention concerne des implants polymères biodégradables qui peuvent constituer des moyens sûrs et efficaces d'administration de médicaments pour le traitement de diverses maladies. Si ce système polymère de libération de médicament se prête à une implantation dans le sujet sous forme d'un dispositif solide, il est également possible d'administrer un tel système sous forme d'un liquide injectable qui se solidifie in vivo. Une formulation améliorée d'un système d'administration de médicament comprend un copolymère insoluble à l'eau qui est un solide ou une cire à 37 ·C, un polymère soluble à l'eau qui est un liquide à 25 ·C, et un médicament hydrophobe. Ces systèmes de libération de médicaments peuvent être administrés par injection et ne nécessitent pas le recours à un agent de traitement toxique ou à des manipulations thermiques compliquées.

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