Polymerized cyclic nitroxide radical compound and use thereof

Details Polymerized cyclic nitroxide radical compound and use thereof Polymerized cyclic nitroxide radical compound and use thereof

C - Chemistry, Metallurgy

08

F

C08F 297/00 (2006.01) A61K 31/787 (2006.01) A61K 49/00 (2006.01) A61P 3/06 (2006.01) A61P 9/12 (2006.01) A61P 29/00 (2006.01) A61P 39/06 (2006.01) C08G 65/32 (2006.01) C08G 85/00 (2006.01) C09K 15/30 (2006.01) A23L 1/30 (2006.01)

Patent

CA 2723118

A method of covalently bonding a cyclic nitroxide radical compound to a hydrophobic block of a specific hydrophylic-phobic block copolymer, and polymerized cyclic nitroxide radical compound copolymerized in this manner, as well as use of such a compound, for instance, in the medical field are provided. The compound demonstrates long term stability in vivo under reductive environment.

Cette invention concerne : un procédé pour lier par covalence un composé radicalaire de nitroxyde cyclique à une séquence hydrophobe d'un copolymère séquencé hydrophile-hydrophobe spécifique; un composé radicalaire de nitroxyde cyclique polymérisé qui est produit par la liaison covalente selon le procédé ci-décrit; et l'utilisation du composé dans le domaine médical ou autre domaine similaire. Le composé présente une stabilité à long terme in vivo dans un environnement réducteur.

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