Polymerized vesicles and compounds for their preparation

Details Polymerized vesicles and compounds for their preparation Polymerized vesicles and compounds for their preparation

C - Chemistry, Metallurgy

07

F

167/163, 260/460

C07F 9/10 (2006.01) A61K 9/10 (2006.01) A61K 9/127 (2006.01) C08F 30/02 (2006.01)

Patent

CA 1222254

ABSTRACT OF THE DISCLOSURE Lower-.omega.-alkenoyloxy-long chain alkanoic anhydrides are synthesized from the .omega.-hydroxyalkanoic acids and are condensed with glycerophosphatidyl cholines to prepare alkenoyloxyalkanoic esters of glycerophosphatidyl cholines. These are used to make vesicles which are then polymerized in situ. These vesicles show improved stability and the rate of leakage of entrapped active ingredients such as drugs can be controlled. They are also used to form a hydrophyllic monolayer on polyethylene.

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