Polymers as a support for combinatorial synthesis

C - Chemistry – Metallurgy – 07 – C

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C07C 205/59 (2006.01) C07B 61/00 (2006.01) C07C 201/12 (2006.01) C07C 201/16 (2006.01) C07C 205/58 (2006.01) C07K 1/04 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2261051

"Three-dimensional" polymers of very small size can be used in the context of synthesis. These polymers provide simple isolation routes by avoiding the need for workup following the reactions, pre-workup characterization, high yield, high capacity and reusability. Of equal importance, these polymers provide a more efficient route to combinatorial synthesis of small molecules. This provides greatly enhanced efficiency for making and screening molecules for physical/biological properties.

Il est possible d'employer des polymères "tridimensionnels" de taille très réduite à une synthèse. Ces polymères, qui constituent des moyens simples d'isolement, évitent d'avoir recours à des traitements conclusifs faisant suite aux réactions et permettent d'effectuer une caractérisation précédant un traitement conclusif; ils garantissent également des rendements élevés et peuvent être réutilisés. Il est également important de remarquer que ces polymères constituent un moyen mieux adapté à la réalisation d'une synthèse combinatoire plus efficace de petites molécules. L'efficacité est accrue, s'agissant de la production de molécules et de criblages relatifs à leurs propriétés physiques/biologiques.

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