C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/536 (2006.01) A61P 5/24 (2006.01) A61P 15/00 (2006.01)
Patent
CA 2603807
Tanaproget polymorph Form II, processes for preparing tanaproget polymorph Form II, pharmaceutical compositions including tanaproget polymorph Fo.pi.n II, micronized tanaproget polymorph Form II, and processes for converting Form II to tanaproget Form I are provided. Also provided are methods of contraception, hormone replacement therapy, stimulation of food intake and treating or preventing uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, or carcinomas and adenocarcinomas comprising administering polymorph Form II to a mammalian subject.
Cette invention concerne une forme II de tanaproget, des procédés d'obtention de cette forme II de tanaproget, des compositions pharmaceutiques contenant la forme II de tanaproget, une forme II polymorphe de tanaproget micronisée, et des procédés permettant de transformer la forme II de tanaproget en une forme I de tanaproget. L'invention concerne également des méthodes de contraception, une thérapie de substitution hormonale, la stimulation de l'ingestion d'aliments ainsi que le traitement ou la prévention de diverses pathologies - fibromyomes utérins, hypertrophie prostatique bénigne, maladies néoplasiques bénignes et malignes, hémorragies dysfonctionnelles, léiomyomatose utérine, endométriose, syndrome ovarien polycystique, ou carcinomes et adénocarcinomes. - par administration à un mammifère de la forme II polymorphe.
Ku Mannching Sherry
Tesconi Marc Sadler
Xu Yan
Torys Llp
Wyeth
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