Polymorph of 5-[4-[2- (n-methyl-n-( 2-pyridyl)amino)...

Details Polymorph of 5-[4-[2- (n-methyl-n-( 2-pyridyl)amino)... Polymorph of 5-[4-[2- (n-methyl-n-( 2-pyridyl)amino)...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/44 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2370280

A polymorphic form of 5-[4-[2- (N-methyl-N-( 2-pyridyl)amino) ethoxy]benzyl] thiazolidine-2, 4-dione, maleic acid salt (the "Polymorph") characterised in that it provides: (i) an infra red spectrum containing peaks at 1763, 912, 856 and 709 cm-1; and/or (ii) a Raman spectrum containing peaks at 1762, 1284, 912 and 888 cm-1; and/or (iii) a solid-state 13C nuclear magnetic resonance spectrum containing peaks at 111.0, 113.6, 119.8, 129.1, 130.9, 131.8, 134.7, 138.7, 146.5, 152.7, 157.5, 169.5, 171.0, 178.7 ppm; and/or (iv) an X-ray powder diffraction (XRPD) pattern which gives calculated lattice spacings at 5.87, 5.30, 4.69, 4.09, 3.88, 3.61, 3.53 and 3.46 Angstroms; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.

L'invention concerne une forme polymorphe du sel d'acide 5-[4-[2- (N-méthyl-N-( 2-pyridyl)amino) éthoxy]benzyl] thiazolidine-2, 4-dione,maléique (la "Polymorphe") caractérisée en ce qu'elle fournit: (i) un spectre infrarouge avec des crêtes à 1763, 912, 856 et 709 cm(-1); et/ou (ii) un spectre Raman avec des crêtes à 1762, 1284, 912 et 888 cm(-1); et/ou (iii) un spectre de résonance magnétique nucléaire de (13)C à l'état solide avec des crêtes à 111,0, 113,6, 119,8, 129,1, 130,9, 131,8, 134,7, 138,7, 146,5, 152,7, 157,5, 169,5, 171,0, 178,7 ppm; et/ou (iv) un diagramme de diffraction des rayon X en poudre (XRPD) qui donne des espacements calculés de réseau à 5,87, 5,30, 4,69, 4,09, 3,88, 3,61, 3,53 et 3,46 Angströms; ainsi qu'un procédé pour préparer ce composé, une composition pharmaceutique contenant ce composé et l'utilisation de ce composé en médecine.

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