Polymorph of {6,7-bis(2-methoxy-ethoxy)-quinazolin-4-yl}-(3e)

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 239/94 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2514977

The invention is concerned with a novel polymorph of [6,7-Bis(2-methoxy- ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. This polymorph exhibits superior properties compared to the previously known forms of [6,7- Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride and can be used as medicament for the treatment of hyperproliferative disorders.

Cette invention a trait à un nouveau polymorphe de of [6,7-Bis(2-méthoxy-éthoxy)-quinazolin-4-yl]-(3-éthynyl-phényl)amine chlorhydrate. Ce polymorphe fait montre de propriétés supérieures par rapport aux formes connues de [6,7-Bis(2-méthoxy-éthoxy)-quinazolin-4-yl]-(3-éthynyl-phényl)amine chlorhydrate. On peut l'utiliser comme médicament aux fins du traitement d'états pathologiques hyperprolifératifs.

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