C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/94 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2514977
The invention is concerned with a novel polymorph of [6,7-Bis(2-methoxy- ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. This polymorph exhibits superior properties compared to the previously known forms of [6,7- Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride and can be used as medicament for the treatment of hyperproliferative disorders.
Cette invention a trait à un nouveau polymorphe de of [6,7-Bis(2-méthoxy-éthoxy)-quinazolin-4-yl]-(3-éthynyl-phényl)amine chlorhydrate. Ce polymorphe fait montre de propriétés supérieures par rapport aux formes connues de [6,7-Bis(2-méthoxy-éthoxy)-quinazolin-4-yl]-(3-éthynyl-phényl)amine chlorhydrate. On peut l'utiliser comme médicament aux fins du traitement d'états pathologiques hyperprolifératifs.
Bubendorf Andre Gerard
Hennig Michael
Hidber Pirmin
Rimmler Goesta
Rohrer Franziska
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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