Polymorph of (r) -3- (2-hydroxy-2, 2-diphenyl-acetoxy) -1-...

Details Polymorph of (r) -3- (2-hydroxy-2, 2-diphenyl-acetoxy) -1-... Polymorph of (r) -3- (2-hydroxy-2, 2-diphenyl-acetoxy) -1-...

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2660983

A novel polymorphic crystal form of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3- ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide, designated crystal form Talpha. Methods for preparing same and the use of the crystal form as the active ingredient of medicaments for the treatment of inflammatory or obstructive airways diseases are also described.

La présente invention concerne une forme cristalline polymorphe innovante du bromure de (R)-3-(2-hydroxy-2,2-diphényl-acétoxy)-1-(isoxazol-3-ylcarbamoyl-méthyl)-1-azonia-bicyclo-[2.2.2]octane, appelée forme cristalline Talpha. L'invention concerne également des procédés de préparation de ladite forme cristalline et l'utilisation de la forme cristalline en tant que matière active de médicaments destinés au traitement de maladies inflammatoires ou de maladies obstructives des voies respiratoires.

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