Polymorphic and amorphous forms of the phosphate salt of...

Details Polymorphic and amorphous forms of the phosphate salt of... Polymorphic and amorphous forms of the phosphate salt of...

C - Chemistry, Metallurgy

07

D

C07D 487/06 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2581025

The present invention relates to novel polymorphic and amorphous forms of a phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5- tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula (1), and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(ADP-ribose) polymerase activity including the disease condition such as cancer.

L'invention concerne des nouvelles formules polymorphes et amorphes d'un sel de phosphate 8-fluoro-2-{4-[(méthylamino)méthyl]phényl}-1,3,4,5-tétrahydro-6H-azépino[5,4,3-cd]indol-6-one ainsi que des procédés pour leur préparation. Lesdites formules polymorphes peuvent être l'un des composants d'une composition pharmaceutique et peuvent être utilisées pour traiter un état pathologique d'un mammifère associé à une activité de la polymérase poly(ADP-ribose) notamment les états pathologiques tels que le cancer.

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