Polymorphic and amorphous salt forms of squalamine dilactate

Details Polymorphic and amorphous salt forms of squalamine dilactate Polymorphic and amorphous salt forms of squalamine dilactate

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/575 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2606077

The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.

Cette invention concerne des sels de squalamine sélectionnés, des méthodes de synthèse desdits sels, leur utilisation thérapeutique et leurs avantages en matière de fabrication, de stabilité et de toxicité de produit. Plus spécifiquement, ladite invention concerne diverses formes du sel de dilactate de squalamine et leur utilité pour inhiber la néovascularisation et la prolifération de cellules endothéliales.

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