C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/404 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2647286
The present invention provides novel polymorphic and pseudopolymorphic forms of Trandolaprilat, including crystalline Trandolaprilat Form A, crystalline Trandolaprilat Form B, crystalline Trandolaprilat Form C, crystalline Trandolaprilat Form D, crystalline Trandolaprilat Form E, and mixtures thereof. The invention also provides novel methods for producing Trandolaprilat, pharmaceutically acceptable salts of Trandolaprilat, and polymorphic and pseudopolymorphic forms of Trandolaprilat, pharmaceutical compositions including one or more novel Trandolaprilat compounds and methods for treating high blood pressure and/or cardiac insufficiency using one or more novel Trandolaprilat compounds.
Cette invention concerne de nouvelles formes polymorphiques et pseudo-polymorphiques de Trandolaprilate, y compris la Forme cristalline A de Trandolaprilate, la Forme cristalline B de Trandolaprilate, la Forme cristalline C de Trandolaprilate, la Forme cristalline D de Trandolaprilate, la Forme cristalline E de Trandolaprilate, et des mélanges de celles-ci. Cette invention concerne également de nouveaux procédés de production de Trandolaprilate, des sels pharmaceutiquement acceptables de Trandolaprilate, des formes polymorphiques et pseudo-polymorphiques de Trandolaprilate, des compositions pharmaceutiques renfermant un ou plusieurs nouveaux composés de Trandolaprilate, ainsi que des méthodes de traitement de l'hypertension artérielle et/ou de l'insuffisance cardiaque utilisant un ou plusieurs nouveaux composés de Trandolaprilate.
Azad Pharmaceutical Ingredients
Gowling Lafleur Henderson Llp
Universitaet Zuerich
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