Polymorphic form of fluoro-7-(2,2,2-trifluoroethoxy)...

C - Chemistry – Metallurgy – 07 – D

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C07D 327/08 (2006.01) A61K 31/38 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2656767

Provided herein is a new form of 3-fluoro-7-(2,2,2-trifluoroethoxy) phenoxathin 10,10-dioxide, which demonstrates higher stability relative to other forms of 3-fluoro-7-(2,2,2-trifluoroethoxy) phenoxathiin-10,10-dioxide. In particular, this new form affords less dosage critical administration of 3-fluoro-7-(2,2,2-trifluoroethoxy) phenoxathin 10,10-dioxide relative to other forms. The new solid form of 3-fluoro-7-(2,2,2-trifluoroethoxy) phenoxathiin-10,10-dioxide has been determined and is provided herein. This new solid form of 3-fluoro-7-(2,2,2-trifluoroethoxy) phenoxathiin-10,10-dioxide can be characterized by any of a number of its properties, including, but not limited to, melting point, differential scanning calorimetry, infrared spectroscopic spectrum or portions thereof, solubility, methods and conditions under which this form is prepared, and/or precipitated from solution, and, when in crystalline form, the crystalline form can be characterized according to the diffraction pattern or portions thereof.

L'invention concerne une nouvelle forme de 3-fluoro-7-(2,2,2-trifluoroéthoxy) phénoxathiine 10,10-dioxyde, qui présente une stabilité supérieure aux autres formes de 3-fluoro-7-(2,2,2-trifluoroéthoxy) phénoxathiine-10,10-dioxyde. En particulier, le dosage critique d'administration de cette nouvelle forme comprend moins de 3-fluoro-7-(2,2,2-trifluoroéthoxy) phénoxathiine 10,10-dioxyde que les autres formes. La nouvelle forme solide de 3-fluoro-7-(2,2,2-trifluoroéthoxy) phénoxathiine-10,10-dioxyde est déterminée et présentée ici. Cette nouvelle forme solide de 3-fluoro-7-(2,2,2-trifluoroéthoxy) phénoxathine-10,10-dioxyde peut être caractérisée par n'importe laquelle de ses ses propriétés, comprenant mais sans y être limitées, le point de fusion, la calorimétrie par analyse différentielle, le spectre en spectroscopie infrarouge ou des parties de celui-ci, la solubilité, les méthodes et les conditions de préparation et/ou de précipitation à partir d'une solution, et, sous une forme cristalline, le diagramme de diffraction ou parties de celui-ci.

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