Polymorphic forms/hydrates of...

Details Polymorphic forms/hydrates of... Polymorphic forms/hydrates of...

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2412535

There are described polymorphic forms/hydrates of N-[4-(3-chloro-4- fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]-acrylamide dihydrochloride, processes for their preparation, as well as the use of the same for the preparation of medicaments with irreversible tyrosine kinase inhibiting action.

L'invention concerne des formes polymorphes/hydrates de N-[4-(3-chloro-4-fluorophénylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]-acrylamide dihydrochlorure, des procédés de leur préparation, ainsi que leurs utilisations dans la préparation de médicaments à action inhibitrice irréversible de la tyrosine kinase.

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