C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2451028
The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3- yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5- cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.
L'invention concerne de nouvelles formes cristallines du chlorhydrate de 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-pipérazine, la forme cristalline du dichlorhydrate de 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-pipérazine et la forme amorphe du chlorhydrate de 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-pipérazine, particulièrement utilisées dans la préparation de médicaments solides pour prévenir ou traiter les troubles dépressifs, les troubles anxieux, les troubles bipolaires, la manie, la démence, les troubles en rapport avec un produit, les dysfonctionnements sexuels, les troubles de l'alimentation, l'obésité, la fibromyalgie, les troubles du sommeil, les troubles psychiatriques, l'infarctus cérébral, les tensions, ainsi que pour traiter les effets secondaires des traitements de l'hypogonadisme, de l'aménorrhée secondaire, du syndrome prémenstruel et de la lactation puerpérale indésirable.
Bartels Matthias
Bathe Andreas
Bottcher Henning
Helfert Bernd
Kniel Heike
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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