C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/06 (2006.01) A61K 31/5517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2648369
The present invention relates to novel polymorphic forms and amorphous form of (2R,Z)-2-amino-2-cyclohexyl-N-(5-(1-methyl-1H-pyrazol-4-yl)-1-oxo-2,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide, and to processes for their preparation. Such polymorphic forms and amorphous form may be a component of a pharmaceutical composition and may be used to treat a cancer or a mammalian disease condition mediated by protein kinase activity.Formula (I).
L'invention concerne de nouvelles formes polymorphes et amorphes de (2R,Z)-2-amino-2-cyclohexyl-N-(5-(1-méthyl-1H-pyrazol-4-yl)-1-oxo-2,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)acétamide, et des procédés de préparation de celles-ci. Ces formes polymorphes et amorphes peuvent être un composant d'une composition pharmaceutique et peuvent être utilisées pour le traitement d'un cancer ou d'un état pathologique d'un mammifère dans lesquels l'activité protéine kinase joue un rôle de médiateur.
Ninkovic Sacha
Rynberg Raymond
Pfizer Products Inc.
Smart & Biggar
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