Polymorphic forms of 4-phenylamino quinazoline derivatives,...

Details Polymorphic forms of 4-phenylamino quinazoline derivatives,... Polymorphic forms of 4-phenylamino quinazoline derivatives,...

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/498 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2719523

The present invention relates to polymorphic forms of N-{4-[3-chloro-4- (3-fluoro-benzyloxy)phenylamino]-quinazolin-6-yl}-acrylamide p- toluenesulfonate with the characteristic X-ray powder diffraction data as stated in the description, preparation methods thereof, pharmaceutical compositions comprising the same and the use thereof.

La présente invention concerne les polymorphes du p-toluènesulfonate de N-{4-[3-chloro -4-(3-fluoro- benzyloxy) phényl-amino] quinazolin-6-yl} acrylamide dont les formes de diffraction de la poudre aux rayons X sont telles que décrites dans la spécification. L'invention concerne également des procédés d'élaboration correspondants, des compositions pharmaceutiques contenant ces polymorphes, et leurs utilisations.

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