Polymorphic forms of phenyl oxazolidinone derivatives

Details Polymorphic forms of phenyl oxazolidinone derivatives Polymorphic forms of phenyl oxazolidinone derivatives

A - Human Necessities

61

K

A61K 31/496 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2483600

The invention relates to phenyl oxazolidinone derivatives. More particularly, it relates to polymorphic forms of (S)-N-~~3-fluoro-4-~N-1~4-{2-furyl-(5- nitro)methyl}~piperazinyl~-phenyl~-2-oxo-5-oxazolidinyl~-methyl~acetamide hydrochloride having the Formula I. Further, the invention relates to methods of using such compounds as antimicrobials, pharmaceutical compositions containing the novel polymorphic forms, and processes for the preparation of the polymorphic forms.

L'invention se rapporte à des dérivés d'oxazolidinone de phényle et plus particulièrement, à des formes polymorphes de (S)-N-ÝÝ3-fluoro-4-ÝN-1Ý4-{2-furyl-(5-nitro)méthyl}¨piperazinyl¨-phényl¨-2-oxo-5-oxazolidinyl¨-méthyl¨acétamide ayant la formule (I). L'invention se rapporte également à des procédés d'utilisation de tels composés comme agents antimicrobiens, à des compositions pharmaceutiques contenant les nouvelles formes polymorphes et à des procédés de préparation des formes polymorphes.

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