Polymorphic forms of sertraline hydrochloride

Details Polymorphic forms of sertraline hydrochloride Polymorphic forms of sertraline hydrochloride

C - Chemistry, Metallurgy

07

C

C07C 211/42 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01)

Patent

CA 2387135

A crystalline form of sertraline hydrochloride was found, referred to hereinafter as polymorphic form CSC2 having a dissolution rate which surprisingly will increase rate of absorption of a drug. Furthermore, different crystalline forms of sertraline hydrochloride alcohol solvates, crystalline forms of sertraline hydrochloride hydrates, referred to hereinafter as polymorphic form CSC1, a process for the preparation of the amorphous form of sertraline hydrochloride, and different processes for the preparation of polymorphic forms I, II, V, and T1 are disclosed.

La présente invention concerne une forme cristalline d'hydrochlorure de sertraline, ci-après désignée sous le nom de forme polymorphique CSC2, présentant une vitesse de dissolution qui, de façon surprenante, va augmenter la vitesse d'absorption d'un médicament. Cette invention concerne également différentes formes cristallines de solvates d'alcool d'hydrochlorure de sertraline, des formes cristallines d'hydrates d'hydrochlorure de sertraline, ci-après désignées sous le nom de forme polymorphique CSC1, un procédé de préparation de la forme amorphe d'hydrochlorure de sertraline, ainsi que différents procédés de préparation de formes polymorphiques I, II, V et T1.

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