Polymorphic salt

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 403/06 (2006.01) A61K 31/404 (2006.01) A61P 25/06 (2006.01)

Patent

CA 2379572

The present invention is concerned with a crystalline, polymorphic form of a compound of formula (I) characterised by a powder X-ray diffraction pattern obtained using copper K-alpha, radiation (.gamma.= 0.15046 nm) which shows main peaks at 9.28, 10.38, 11.37, 12.40, 16.84, 17.46, 17.53, 17.78, 17.98, 19.48. 20.70, 21.29, 21.45, 22.21, 22.64, 23.08, 25.20 and 25.79. The invention also relates to processes for the preparation of said form, to pharmaceutical compositions containing same and to its use in medicine, particularly the treatment of conditions for which an agonist of 5- IIT~ receptors is indicated, for example, migraine,

L'invention concerne une forme polymorphe cristalline d'un composé de formule (I), caractérisé par une figure de diffraction à rayons X en poudre, obtenue en utilisant une radiation K-alpha1 de cuivre ( gamma = 0.15046mm) qui présente des pics principaux à 9,2; 10,38 ; 11,37 ; 12,40 ; 16,84 ; 17,46 ; 17,53 ; 17,78 ; 17,98 ; 19,48 ; 20,70 ; 21,29 ; 21,45 ; 22,21 ; 22,64 ; 23,08 ; 25,20 et 25,79. L'invention concerne également des procédés de préparation de ladite forme, afin d'obtenir des compositions pharmaceutiques contenant la forme susmentionnée et son utilisation médicale, en particulier dans le traitement des conditions pour lesquelles des récepteurs agonistes de 5-HT1 sont indiqués, la migraine, par exemple.

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