Polymorphism detection utilizing clustering analysis

Details Polymorphism detection utilizing clustering analysis Polymorphism detection utilizing clustering analysis

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12P 19/34 (2006.01) G05B 15/00 (2006.01) G06K 9/00 (2006.01)

Patent

CA 2299625

Systems and methods for detecting differences in sample polymers, such as nucleic acid sequences, are provided. Hybridization affinity information for the sample polymers is clustered so that the differences, if any, between or among the sample polymers can be readily identified. By clustering the hybridization affinity information of the sample polymers, differences in the sample polymers can be accurately achieved even in the presence of random and systematic errors.

L'invention porte sur des systèmes et procédés permettant de détecter des différences dans des échantillons de polymères tels que des séquences d'acides nucléiques. Les informations d'affinité d'hybridation relatives aux échantillons de polymères sont mises en grappes si bien que les éventuelles différences entre ou parmi les échantillons de polymères peuvent facilement être identifiées. La mise en grappes des informations d'affinité d'hybridation relatives aux échantillons de polymères permet de détecter avec précision leurs différences, même en présence d'erreurs aléatoires et systématiques.

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