Polymorphisms associated with age-related macular...

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 21/04 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2721503

The present invention provides for certain polynucleotide sequences that have been correlated to AMD. These polynucleotides are useful as diagnostics, and are preferably used to fabricate an array, useful for screening patient samples. The array is used as part of a laboratory information management system, to store and process additional patient information in addition to the patient's genomic profile. As described herein, the system provides an assessment of the patient's risk for developing AMD, risk for disease progression, and the likelihood of disease prevention based on patient controllable factors.

La présente invention concerne certaines séquences de polynucléotides qui ont été corrélées à lAMD. Ces polynucléotides sont utiles en tant que diagnostics, et sont de préférence utilisés pour fabriquer un réseau utile pour cribler des échantillons de patients. Le réseau est utilisé dans le cadre dun système de gestion des informations en laboratoire, pour stocker et traiter des informations supplémentaires sur un patient en plus du profil génomique du patient. Tel que décrit dans le présent document, le système permet une évaluation du risque du patient de développer une AMD, du risque dévolution de la maladie et de la probabilité de prévention de la maladie en fonction des facteurs contrôlables du patient.

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