Polymorphisms for predicting disease and treatment outcome

Details Polymorphisms for predicting disease and treatment outcome Polymorphisms for predicting disease and treatment outcome

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2494262

The invention provides compositions and methods for determining the increased risk for recurrence of certain cancers and the likelihood of successful treatment with one or both of chemotherapy and radiation therapy. The methods comprising determining the type of genomic polymorphism present in a predetermined region of the gene of interest isolated from the subject or patient. Also provided are nucleic acid probes and kits for determining a patient's cancer risk and treatment response.

L'invention concerne des compositions et des procédés destiné à déterminer le risque aggravé de récurrence de certains cancers et la vraisemblance de traitement réussi au moyen de la chimiothérapie, de la radiothérapie ou des deux. Les procédés consistent à déterminer le type de polymorphisme génomique présent dans une zone prédéfinie du gène d'intérêt isolé du sujet ou du patient. L'invention concerne également des sondes et des nécessaires d'acide nucléique destinés à déterminer un risque de cancer chez un patient ainsi qu'une réaction au traitement.

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