Polymorphisms predictive of anthracycline-induced...

Details Polymorphisms predictive of anthracycline-induced... Polymorphisms predictive of anthracycline-induced...

C - Chemistry, Metallurgy

40

B

C40B 40/06 (2006.01) A61K 31/65 (2006.01) A61K 31/704 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01)

Patent

CA 2669131

Provided are methods, nucleic acids, and arrays for assessing the susceptibility of a subject to the development of cardiotoxicity in response to receiving one or more anthracycline compounds, the method including determining the presence or absence of one or more polymorphisms, wherein the presence or absence of one or more such polymorphisms is indicative of susceptibility to the development of cardiotoxicity.

La présente invention concerne des méthodes, des acides nucléiques et des réseaux permettant d'évaluer la prédisposition d'un sujet à développer une cardiotoxicité en réponse à l'administration d'un ou plusieurs composés anthracycline, laquelle méthode consiste à déterminer la présence ou l'absence d'un ou plusieurs polymorphismes, la présence ou l'absence de ce ou ces polymorphismes indiquant la prédisposition à développer une cardiotoxicité.

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