C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 40/08 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01) C40B 40/10 (2006.01)
Patent
CA 2669135
Provided are methods, nucleic acids, and arrays for assessing the susceptibility of a subject to the development of ototoxicity in response to receiving one or more platinum-coordinating compounds, the method including determining the presence or absence of one or more polymorphisms, wherein the presence or absence of one or more such polymorphisms is indicative of susceptibility to the development of ototoxicity.
La présente invention concerne des méthodes, des acides nucléiques et des réseaux permettant d'évaluer la prédisposition d'un sujet à développer une ototoxicité en réponse à l'administration d'un ou plusieurs composés de coordination du platine, laquelle méthode consiste à déterminer la présence ou l'absence d'un ou plusieurs polymorphismes, la présence ou l'absence de ce ou ces polymorphismes indiquant la prédisposition à développer une ototoxicité.
Carleton Bruce
Hayden Michael
Ross Colin
Smart & Biggar
The University Of British Columbia
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