Polymorphous forms of rifaximin, processes for their...

Details Polymorphous forms of rifaximin, processes for their... Polymorphous forms of rifaximin, processes for their...

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) A61K 31/4188 (2006.01) A61P 31/00 (2006.01) C07D 498/22 (2006.01)

Patent

CA 2460384

Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin .alpha. and rifaximin .beta. and a poorly crystalline form named rifaximin .gamma. have been discovered. These forms are useful in the production of medicinal preparations for oral and topical use and can be obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by the addition of water at a determinate temperature and for a determinate period of time. The crystallization is followed by drying carried out under controlled conditions until a specific water content is reached in the end product.

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