Polymorphs of a c-met/hgfr inhibitor

Details Polymorphs of a c-met/hgfr inhibitor Polymorphs of a c-met/hgfr inhibitor

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4155 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2632283

This invention relates to polymorphs of (R)-3-[1- (2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl- 1H-pyrazol-4-yl)-pyridin-2-ylamine represented by formula 1 that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to compositions including such salts and polymorphs, and to methods of using such compositions in the treatment of abnormal cell growth in mammals, especially humans. (see formula 1)

L'invention concerne des polymorphes de (R)-3-[1-(2,6-dichloro-3-fluoro-phényl)-éthoxy]-5-(1- pipéridin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine utiles dans le traitement d'une croissance cellulaire anormale, telle qu'un cancer, chez des mammifères. L'invention concerne également des méthodes d'utilisation de ces compositions dans le traitement d'une croissance cellulaire anormale chez des mammifères, et notamment chez l'homme.

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