Polymorphs of acyl sulfonamides

Details Polymorphs of acyl sulfonamides Polymorphs of acyl sulfonamides

C - Chemistry, Metallurgy

07

C

C07C 311/51 (2006.01) C07C 303/44 (2006.01)

Patent

CA 2735192

The application discloses novel polymorphic crystalline forms of 2-[4-Bromo-3- (3-chloro-5-cyano-phenoxy)-2- fluoro-pnenyl]-N-(2-chloro-4-propionylsulfamoyl-phenyl)-acetamide, sodium salt (Ib) with improved stability and physical properties which facilitate manufacturing, handling and formulating for treatment or prophylaxis of HIV mediated diseases, AIDS or ARC, in monotherapy or in combination therapy.

Cette invention concerne de nouvelles formes cristallines polymorphes du 2-[4-bromo-3-(3-chloro-5-cyano-phénoxy)-2-fluoro-phényl]-N-(2-chloro-4- propionylsulfamoylphényl)acétamide, sel de sodium (Ib), ayant une stabilité et des propriétés physiques améliorées qui facilitent la fabrication, la manipulation et la formulation pour traiter ou prévenir les maladies médiées par le VIH, le SIDA ou l'ARC, en monothérapie ou thérapie combinée.

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