Polymorphs of clopidogrel hydrogensulfate

C - Chemistry – Metallurgy – 07 – D

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C07D 495/04 (2006.01) A61K 31/4365 (2006.01)

Patent

CA 2470479

Provided are new crystalline Forms III, IV, V and VI of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. Also provided are novel processes for preparation of clopidogrel hydrogensulfate Form I, Form II, Form III, Form IV, Form V, Form VI and amorphous form.

L'invention concerne de nouvelles formes cristallines III, IV, V et VI d'hydrogénosulfate de clopidogrel et la forme amorphe de cet hydrogénosulfate, de même que leurs compositions pharmaceutiques et un procédé de traitement au moyen de ces compositions. L'invention concerne également de nouveaux procédés de préparation d'drogénosulfate de clopidogrel de formes I, II, III, IV, V, VI et de forme amorphe.

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