Polymorphs of hydrochloride salt of...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2721595

Polymorphic forms of the hydrochloride salt of 5-(3-(ethylsulfonyl)phenyl)-3,8- dimethyl-N-(1 -methylpiperidin-4--yl)-9h-pyrido[2,3-b]indole-7-carboxamide (referred to herein as Compound 1) which has the formula: and compositions thereof, wherein the Compound 1 is present in one or more polymorphic forms. Also provided are novel methods for the preparation of the polymorphs of Compound 1, and kits and articles of manufacture of the compositions, and methods of using the compositions to treat a disease state for which a kinase possesses activity that contributes to the pathology selected from the group consisting of cancer, dementia related diseases and arthritis.

L'invention porte sur des formes polymorphes du sel chlorhydrate de 5-(3-(éthylsulfonyl)phényl)-3,8-diméthyl-N-(1-méthylpipéridin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide (appelé ici Composé 1) qui a la formule : et sur des compositions à la base de celui-ci, le Composé 1 étant présent sous une ou plusieurs formes polymorphes. L'invention porte également sur de nouveaux procédés pour la préparation des polymorphes du Composé 1, et sur des coffrets et articles de fabrication des compositions, et sur des procédés d'utilisation des compositions pour traiter un état de maladie pour lequel une kinase possède une activité qui contribue à la pathologie choisie dans le groupe constitué par le cancer, les maladies liées à la démence et l'arthrite.

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