Polymorphs of o-desmethyl venlafaxine succinate

C - Chemistry – Metallurgy – 07 – C

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C07C 215/64 (2006.01) A61K 31/136 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2665381

T h e present invention relates to crystalline forms of O-desmethyl venlafaxine ( O D V ) succinate monohydrate, namely Forms I and II, in pure form and to novel processes for their preparation. The present invention provides a process for the preparation of Form II free of Form I and a process for the preparation of Form I free of Form II. The present invention provides direct methods f o r the preparation of ODV succinate Form II from ODV free base a n d for the preparation of ODV succinate Form I from ODV free base.

La présente invention concerne des formes cristallines de succinate monohydraté d'O-desméthyl venlafaxine (ODV), à savoir les formes I et II, sous une forme pure, et de nouveaux procédés pour leur préparation. La présente invention concerne un procédé pour la préparation de la forme II sans la forme I et un procédé pour la préparation de la forme I sans la forme II. La présente invention propose des procédés directs pour la préparation de succinate d'ODV de forme II à partir d'une base ne contenant pas d'ODV et pour la préparation de succinate d'ODV de forme I à partir d'une base ne contenant pas d'ODV.

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