Polymorphs of s-omeprazole

Details Polymorphs of s-omeprazole Polymorphs of s-omeprazole

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2517714

This invention relates to polymorphic forms of the S-enantiomer of omeprazole which is S-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]- 1H~benzimidazole. The invention also relates to processes for preparing the polymorphic forms. More particularly, it relates to the preparation of two polymorphic forms of S~omeprazole, referred to as 'Form I' and 'Form II' and pharmaceutical compositions that include the 'Form I' and 'Form II'.

L'invention porte sur les formes polymorphiques de S-enantiomère d'oméprazole dont la formule chimique est S-5-méthoxy-2-[[(4-méthoxy-3,5-diméthyle-2-pyridinyle)-méthyle]sulfinyle]-1H-benzimidazole. L'invention porte également sur les procédés de fabrication des formes polymorphiques. En particulier, elle porte sur la confection de deux formes polymorphiques de S-oméprazole, dénommées <=Forme I >= et <= Forme II >= et des compositions pharmaceutiques qui renferment les <= Forme I >= et <= Forme II >=.

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