Polymyxin methyl tetracycline

Details Polymyxin methyl tetracycline Polymyxin methyl tetracycline

A - Human Necessities

61

K

530/7.62

A61K 31/65 (2006.01) A61K 9/08 (2006.01)

Patent

CA 1070675

ABSTRACT OF THE DISCLOSURE The present invention relates to the new antibiotic polymyxine methyl tetracycline wide spectrum salts of the general formula [TH+-CO-NH-CH2-NH)n-P, nA=], m HB- in which m and n represent positive integers of less than 6, A= and B- represent mineral or organic anions, T represents an antibiotic residue of the tetracycline family having a primary amide function and the formula T-CONH2, P represents a polypeptidic antibiotic residue of the polymyxine family of the formula P-(NH2)n, and particularly tri-(oxytetra- cycline methyl) colistine trichloride-sulfate. The present invention also relates to the methods of preparing antibiotic salts by preparing the methylols of tetracycline salts by the addition of formol to the treacycline salts, then, with or without isolation of this intermediate product, condens- ing it with an antibiotic of the polymyxine family. The present invention also relates to medications and pharma- ceutical forms containing the products of the invention.

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