Polynucleotide analogs, methods for inhibiting nucleic acid...

Details Polynucleotide analogs, methods for inhibiting nucleic acid... Polynucleotide analogs, methods for inhibiting nucleic acid...

C - Chemistry, Metallurgy

07

H

167/202, 195/1.1

C07H 21/00 (2006.01) A61K 31/70 (2006.01)

Patent

CA 1295269

RFP:414 NOVEL POLYNUCLEOTIDE ANALOGS, METHODS FOR INHIBITING NUCLEIC ACID POLYMERASES AND METHODS FOR INDUCING SYNTHESIS OF INTERFERON ABSTRACT OF THE DISCLOSURE Polyribonucleotide analogs which are partially substituted by the introduction of mercapto groups and fluorine at the 5- position of some of their cytosine and uracil bases possess effective in vivo antitumor activity. Double stranded complexes formed from such polynucleotides are especially active as interferon inducers.

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