C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/29 (2006.01) C12N 15/82 (2006.01)
Patent
CA 2359396
A method is disclosed for constructing a synthetic polynucleotide from which a protein is selectively expressible in a target cell of a plant, relative to another cell of the plant. The method comprises selecting a first codon of a parent polynucleotide for replacement with a synonymous codon which has a higher translational efficiency in the target cell than in said other cell, and replacing said first codon with said synonymous codon to form said synthetic polynucleotide.
L'invention concerne un procédé permettant de construire un polynucléotide synthétique à partir duquel une protéine est exprimée de manière sélective dans une cellule cible d'une plante, par rapport à une autre cellule de cette plante. Ce procédé consiste à sélectionner un premier codon d'un polynucléotide parent en vue de son remplacement par un codon synonyme qui possède une plus grande efficacité de traduction dans la cellule cible que dans l'autre cellule, et à remplacer le premier codon par le codon synonyme pour former le polynucléotide synthétique.
Botella Mesa Jose Ramon
Frazer Ian Hector
Zhou Jian
Fetherstonhaugh & Co.
The University Of Queensland
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