Polynucleotide assay reagent and method

Details Polynucleotide assay reagent and method Polynucleotide assay reagent and method

C - Chemistry, Metallurgy

12

Q

150/3, 150/8.5

C12Q 1/68 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 14/00 (2006.01)

Patent

CA 1268404

Abstract A diagnostic reagent and system for determination of a single-stranded polynucleotide analyte having a selected target sequence. The reagent includes a solid support and multiple support-bound polymers designed to bind specifically to the analyte. Each polymer is composed of a sequence of base-complementary recognition moieties which can bind specifically to corresponding in-sequence bases in the analyte target sequence, and an unbranched, stereoregular backbone whose charge density is substantially less than that of the polynucleotide analyte. A reporter in the system contains a polycationic tail adapted to bind to the analyte, under conditions in which the reporter does not bind to the less densely charged polymers, and reporter groups by which the presence of the reporter can be detected.

504320

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