Polynucleotide crosslinking agents

Details Polynucleotide crosslinking agents Polynucleotide crosslinking agents

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07C 45/64 (2006.01) C07C 45/71 (2006.01) C07C 45/74 (2006.01) C07F 9/24 (2006.01)

Patent

CA 2348821

Novel aryl derivatives comprising an aryl olefin moiety linked to a non- nucleosidic backbone moiety are disclosed. The resulting molecules are typically used as photoactivated crosslinking groups when incorporated into oligonucleotides to crosslink nucleic acid strands.

Cette invention se rapporte à de nouveaux dérivés aryle comprenant une fraction aryloléfine liée à une fraction squelette non nucléosidique. Les molécules qui en résultent sont généralement utilisées comme groupes de réticulation photoactivés qui, incorporés dans des oligonucléotides, servent à la réticulation de brins d'acide nucléique.

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