C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 38/48 (2006.01) C07K 16/40 (2006.01) C12N 9/48 (2006.01) C12N 9/64 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G06F 17/00 (2006.01) G06F 19/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2443393
The present invention provides novel polynucleotides encoding CAN-12 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of CAN-12 polypeptides, CAN-12v1 and CAN-12v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel CAN-12, CAN-12v1, and CAN-12v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly neuro- and musculo-degenerative conditions. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
La présente invention concerne de nouveaux polynucléotides codant pour CAN-12, leurs fragments et homologues. Elle concerne aussi des polynucléotides codant pour les variantes de CAN-12, CAN-12v1 et CAN-12v2, de même que des vecteurs, cellules hôtes, anticorps et procédés recombinants et synthétiques pour produire ces polypeptides. L'invention se rapporte aussi aux procédés diagnostiques et thérapeutiques pour appliquer ces nouveaux polypeptides CAN-12, CAN-12v1 et CAN-12v2 à la diagnostique, le traitement et/ou la prévention de diverses maladies et/ou troubles liés à ces polypeptides et notamment des états neuro- et musculodégénératifs. L'invention concerne enfin des procédés de criblage visant à identifier les agonistes et les antagonistes des polynucléotides et polypeptides de la présente invention.
Chen Jian
Duclos Franck
Feder John N.
Nelson Thomas C.
Seiler Steven
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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