A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2438863
The present invention provides novel polynucleotides encoding K+betaM6 polypeptides (Figure 1), fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+betaM6 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
L'invention concerne des polynucléotides codant des polypeptides K+betaM6, y compris leurs fragments et homologues. L'invention concerne également des vecteurs, des cellules hôtes, des anticorps, ainsi que des procédés de recombinaison et de synthèse permettant d'établir ces polypeptides. L'invention concerne en outre des procédés diagnostiques et thérapeutiques permettant d'appliquer les polpypetides K+bêtaM6 considérés, au diagnostic, au traitement et/ou à la prévention de différents types de maladies et/ou de troubles liés à ces polypeptides. L'invention concerne enfin des procédés de criblage permettant d'identifier des agonistes et des antagonistes pour les polynucléotides et les polypeptides décrits.
Chang Han
Chen Jian
Feder John
Jackson Donald G.
Lee Liana
Bristol Myers Squibb Company
Gowling Lafleur Henderson Llp
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