C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 19/34 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2427741
The present invention provides novel polynucleotides encoding K+alphaM1 polypeptides, fragments and homologues thereof. The invention also provides novel polynucleotides encoding the K+alphaM1 variant polypeptides, K+alphaM1.v1 and K+alphaM1.v2, in addition to fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+alphaM1, K+alphaM1.v1, and K+alphaM1.v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
L'invention concerne de nouveaux polynucléotides codant pour les polypeptides K+alphaM1, des fragments et des homologues de ceux-ci. L'invention concerne également de nouveaux polynucléotides codant pour des polypeptides variants de K+alphaM1 : K+alphaM.v1 et K+alphaM1.v2, ainsi que des fragments et des homologues de ceux-ci. Des vecteurs, des cellules hôtes, des anticorps et des procédés de recombinaison et de synthèse permettant la production desdits polypeptides sont également décrits L'invention concerne en outre des méthodes de diagnostic et de traitement comprenant l'utilisation de ces nouveaux polypeptides K+alphaM1, K+alphaM1v.1 et K+alphaM1v.2 pour le diagnostic, le traitement et/ou la prévention de maladies et/ou troubles divers associés à ces polypeptides. L'invention concerne de plus des procédés de criblage permettant d'identifier les agonistes et les antagonistes des polynucléotides et des polypeptides décrits.
Chang Han
Chen Jian
Feder John Nathan
Jackson Donald
Lee Liana M.
Bristol Myers Squibb Company
Gowling Lafleur Henderson Llp
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