C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/42 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12P 21/06 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2441665
The present invention provides novel polynucleotides encoding APEX4 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of APEX4 polypeptides, APEX4v1 and APEX4sv1, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel APEX4, APEX4v1, and APEX4sv1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
L'invention concerne de nouveaux polynucléotides codant des polypeptides APEX4, ainsi que des fragments et homologues de ces derniers. L'invention concerne également des polynucléotides codant des variants et des variants d'épissage de polypeptides APEX4, APEX4v1 etAPEX4sv1, respectivement. Elle concerne en outre des vecteurs, des cellules hôtes, des anticorps, ainsi que des procédés de recombinaison et de synthèse permettant de produire lesdits polypeptides. L'invention concerne également des procédés diagnostiques et thérapeutiques conçus pour appliquer ces nouveaux polypeptides APEX4, APEX4v1 etAPEX4sv1 au diagnostic, au traitement et/ou à la prévention de diverses maladies et/ou troubles en relation avec ces polypeptides. L'invention concerne enfin des procédés de criblage permettant d'identifier des agonistes et antagonistes desdits polynucléotides et polypeptides.
Bristol Myers Squibb Company
Gowling Lafleur Henderson Llp
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