C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2447948
The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP- PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Cette invention se rapporte à de nouveaux polynucléotides codant les polypeptides TRP-PLIK2, des fragments et des homologues de ceux ci. Cette invention concerne également des polynucléotides codant des variants et des variants d'épissage des polypeptides TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c et TRP-PLIK2d, respectivement. Sont également décrits des vecteurs, des cellules hôtes des anticorps et des procédés de recombinaison et de synthèse visant à produire ces polypeptides. Cette invention concerne en outre des procédés diagnostiques et thérapeutiques servant à appliquer ces polypeptides TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c et TRP-PLIK2d au diagnostic, au traitement et/ou à la prévention de diverses maladies et/ou divers troubles associés à ces polypeptides, ainsi que des procédés de criblage permettant d'identifier des agonistes et des antagonistes de ces polynucléotides et polypeptides.
Blanar Michael
Bol David
Chang Han
Chen Jian
Feder John
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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