C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2744064
The present invention provides methods of obtaining structural information about a biopolymer sample. The meth-ods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
La présente invention concerne des procédés dobtention dinformations structurales sur un échantillon de biopolymère. Les procédés comprennent le marquage de portions dun biopolymère, tel quun ADN ou un ARN, la linéarisation du biopolymère dans certains cas, et la détermination de la distance entre les marqueurs. Lutilisateur peut ensuite comparer les distances entre marqueurs de différents échantillons pour comparer qualitativement différents échantillons et analyser un échantillon donné pour rechercher des additions ou délétions de nucléotides dans les régions flanquées par les marqueurs. Les procédés permettent en outre le séquençage de biopolymères.
Boyce-Jacino Michael
Cao Han
Deshpande Parikshit A.
Xiao Ming
Bionano Genomics Inc.
Bionanomatrix Inc.
Gowling Lafleur Henderson Llp
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