Polynucleotide molecules encoding neospora proteins

Details Polynucleotide molecules encoding neospora proteins Polynucleotide molecules encoding neospora proteins

C - Chemistry, Metallurgy

12

N

C12N 15/30 (2006.01) A61K 31/70 (2006.01) A61K 39/002 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/44 (2006.01) C07K 16/20 (2006.01) C12N 1/11 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2264260

The present invention provides isolated polynucleotide molecules comprising nucleotide sequences encoding GRA1, GRA2, SAG1, MIC1 and MAG1 proteins from Neospora caninum, as well as recombinant vectors, transformed host cells, and recombinantly-expressed proteins. The present invention further provides a polynucleotide molecule comprising the nucleotide sequence of the bidirectional GRA1/MAG1 promoter of N. caninum. The present invention further provides genetic constructs based on the polynucleotide molecules of the present invention that are useful in preparing modified strains of Neospora cells for use in vaccines against neosporosis.

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