A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/20 (2006.01) A61K 39/00 (2006.01) A61P 3/04 (2006.01) A61P 7/12 (2006.01) A61P 19/02 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2435758
This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or - peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or - peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non- physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.
L'invention concerne un procédé de traitement ou de prévention de maladie chez un animal associée à au moins une auto-protéine, un auto-polypeptide ou un auto-peptide présent ou impliqué dans un processus non-physiologique chez ledit animal, qui consiste à lui administrer un auto-vecteur comprenant un polynucléotide codant pour l'auto-protéine, l'auto-polypeptide ou l'auto-peptide associé à ladite maladie. L'administration de l'auto-vecteur comprenant un polynucléotide codant pour l'auto-protéine, l'auto-polypeptide ou l'auto-peptide module une réponse immune à l'auto-protéine, l'auto-polypeptide ou l'auto-peptide exprimé à partir de l'administration de l'auto-vecteur. L'invention concerne également une composition, comprenant un polynucléotide codant pour au moins une auto-protéine, un auto-polypeptide ou un auto-peptide présent de manière non-physiologique chez un animal traité, qui peut servir dans le traitement ou la prévention d'une maladie associée à l'auto-protéine, l'auto-polypeptide ou l'auto-peptide présent dans un processus non physiologique chez l'animal et/ou ciblé par ledit processus.
Fontoura Paulo
Garren Hideki
Robinson William H.
Ruiz Pedro Jose
Steinman Lawrence
Fetherstonhaugh & Co.
The Board Of Trustees Of The Leland Stanford Junior University
LandOfFree
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