C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/60 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 38/22 (2006.01) A61K 38/43 (2006.01) A61K 38/44 (2006.01) A61K 38/46 (2006.01) A61K 38/48 (2006.01) A61K 38/51 (2006.01) A61K 38/53 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 19/08 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 14/575 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/26 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 9
Patent
CA 2638823
This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling, variants and derivatives of the polynucleotides and corresponding polypeptides, uses of the polynucleotides, polypeptides, variants and derivatives, and methods and compositions for the amelioration of symptoms caused by bone remodeling disorders. Disclosed in particular are the isolation and identification of polynucleotides polypeptides variants and derivatives involved in osteoclast activity, validation of the identified polynucleotides for their potential as therapeutic targets and use of the polynucleotides, polypeptides, variants and derivatives for the amelioration of disease states and research purposes.
La présente invention concerne notamment des polynucléotides génétiques uniques et nouvellement identifiés intervenant dans le processus de remodelage osseux, des variants et des dérivés des polynucléotides et des polypeptides correspondants, les utilisations des polynucléotides, polypeptides, variants et dérivés, ainsi que des méthodes et compositions destinées à atténuer les symptômes dus aux troubles du remodelage osseux. Cette invention concerne en particulier l'isolement et l'identification de polynucléotides, polypeptides, variants et dérivés intervenant dans l'activité des ostéoclastes, la validation des polynucléotides identifiés pour leur potentiel en tant que cibles thérapeutiques et l'utilisation des polynucléotides, polypeptides, variants et dérivés pour l'amélioration d'états pathologiques ainsi qu'à des fins de recherche.
Filion Mario
Sooknanan Roy Rabindranauth
Tremblay Gilles Bernard
Alethia Biotherapeutics Inc.
Forget Janique
LandOfFree
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