C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 37/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2444696
The present invention provides polynucleotides encoding NF-kB-associated polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these NF-kB-associated polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
L'invention concerne des polynucléotides codant des polypeptides associés à NF-kB, des fragments et des homologues de ceux-ci. Elle concerne également des vecteurs, des cellules hôtes, des anticorps, ainsi que des procédés de recombinaison et de synthèse destinés à produire lesdits polypeptides. L'invention concerne en outre des procédés de diagnostic et de thérapie permettant d'appliquer ces polypeptides associés à NF-kB au diagnostic, au traitement et/ou à la prévention des diverses maladies et/ou troubles liés à ces polypeptides. L'invention concerne enfin des procédés de criblage permettant d'identifier des agonistes et des antagonistes desdits polynucléotides et polypeptides.
Carman Julie
Feder John
Nadler Steven
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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