Polynucleotides and polypeptides associated with trophoblast...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) A61P 9/12 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C07K 16/32 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2619256

The invention relates to polypeptides and polynucleotides associated with trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, and uses of same in the prevention, diagnosis and treatment of conditions requiring regulation of trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover. In particular aspects, diagnostic methods are disclosed for evaluating conditions such as preeclampsia utilizing matador polypeptides and polynucleotides encoding same.

L'invention concerne des polypeptides et des polynucléotides associés à la mort cellulaire des trophoblastes, à la différentiation, à l'invasion, et/ou à la fusion ou au renouvellement des cellules, ainsi que leur utilisation dans la prévention, le diagnostic et le traitement des états nécessitant la régulation de la mort cellulaire des trophoblastes, de la différentiation, de l'invasion, et/ou de la fusion ou du renouvellement des cellules. Dans des aspects particuliers, l'invention concerne des procédés diagnostiques pour évaluer des conditions telles que la prééclampsie au moyen de polypeptides et de polynucléotides matadors les codant.

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