Polynucleotides associated with age-related macular...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2705500

The present invention provides for certain polynucleotide sequences that have been correlated to AMD. These polynucleotides are useful as diagnostics, and are preferably used to fabricate an array, useful for screening patient samples. The array is used as part of a laboratory information management system, to store and process additional patient information in addition to the patient's genomic profile. As described herein, the system provides an assessment of the patient's risk for developing AMD, risk for disease progression, and the likelihood of disease prevention based on patient controllable factors.

La présente invention concerne certaines séquences polynucléotidiques qui sont été corrélées à la dégénérescence maculaire liée à l'âge (AMD). Ces polynucléotides sont utiles en tant que produits de diagnostic, et sont, de préférence, utilisés pour fabriquer un réseau, utile pour cribler des échantillons de patient. Le réseau est utilisé comme partie d'un système de gestion d'informations de laboratoire, pour stocker et traiter des informations de patient supplémentaires en plus du profil génomique du patient. Comme décrit ici, le système fournit une évaluation du risque du patient de développer une dégénérescence maculaire liée à l'âge, du risque de progression de la maladie, et de la probabilité de la prévention de la maladie sur la base des facteurs contrôlables du patient.

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