Polynucleotides encoding a metalloprotease, mp-1

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 9/50 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2437542

The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

La présente invention concerne des polynucléotides codant de nouveaux polypeptides MP-1 ainsi que pour des fragments et homologues de ces derniers. L'invention se rapporte en outre à des vecteurs, des cellules hôtes, des anticorps ainsi qu'à des méthodes de synthèse et de recombinaison génétique destinées à produire lesdits polypeptides. L'invention concerne également des méthodes diagnostiques et thérapeutiques pour appliquer ces nouveaux polypeptides MP-1 au diagnostic, au traitement et/ou à la prévention de divers troubles et maladies liés à ces polypeptides. L'invention se rapporte par ailleurs à des méthodes de criblage destinées à identifier des agonistes et des antagonistes des polynucléotides et polypeptides faisant l'objet de la présente invention.

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